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用大剂量Ara-C治疗顽固性急粒(AML)有许多问题。早期的毒性为粘膜破溃。但更多的资料证明,间断大剂量使用Ara-C可引起严重的神经毒性,每疗程总剂量>18g/m~2时出现。作者认为用较小剂量时,神经毒性有高发倾向。病人与方法1982—1985年,7例女性和8例男性病人接受了大剂量Ara-C治疗。平均年龄37岁。14例AML,1例慢粒急变。9例未治的AML为1组,诱导缓解方案为:正定霉素500g/m~2,第1和第2天静注;第1—7天,
There are many problems with high-dose Ara-C in the treatment of refractory acute pellets (AML). Early toxicity mucosal ulceration. However, more data demonstrate that intermittent high doses of Ara-C can cause severe neurotoxicity, the total dose per treatment> 18g / m ~ 2 appear. The authors believe that with smaller doses, neurotoxicity has a high tendency. Patients and Methods Between 1982 and 1985, seven women and eight male patients underwent high-dose Ara-C treatment. The average age is 37 years old. 14 cases of AML, 1 case of chronic granulocyte blast crisis. 9 cases of untreated AML as a group, the induction of remission program: ningingmycin 500g / m ~ 2, 1 and 2 days intravenous; 1-7 days,