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A novel biodegradable copolymer,poly(5,5-dibromomethyltrimethylene carbonate-co-ε-caprolactone)(poly(DBTC-co-CL)) with pendant bromine groups,was synthesized via ring-opening polymerization(ROP) ofε-caprolactone(CL) and 5,5- dibromomethyltrimethylene carbonate(DBTC) using stannous octoate(Sn(Oct)_2) as catalyst.Then the pendant bromine groups were completely converted into azide form,which permitted“click”reaction with alkyne-terminated polyethylene(A-PEG) by Huisgen 1,3-dipolar cycloadditions preparing biodegradable amphiphilic poly(DTC-co-CL)-g-PEG graft copolymer.The graft copolymer was characterized by nuclear magnetic resonance(NMR) and size-exclusion chromatography(SEC).
A novel biodegradable copolymer, poly (5,5-dibromomethyltrimethylene carbonate-co-ε-caprolactone) (poly (DBTC-co-CL)) with pendant bromine groups, was synthesized via ring-opening polymerization (ROP) of ε-caprolactone ) and 5,5-dibromomethyltrimethylene carbonate (DBTC) using stannous octoate (Sn (Oct) _2) as catalyst.Then the pendant bromine groups were completely converted into azide form, which permitted “click ” reaction with alkyne-terminated polyethylene A-PEG) by Huisgen 1,3-dipolar cycloadditions preparing biodegradable amphiphilic poly (DTC-co-CL) -g-PEG graft copolymer. The graft copolymer was characterized by nuclear magnetic resonance (NMR) and size- exclusion chromatography (SEC) .