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目的探讨p73a和血管内皮生长因子-C(VEGF-C)在子宫内膜癌发生发展过程中的作用。方法采用免疫组织化学S-P法检测正常子宫、增生期子宫、子宫内膜癌组织中p73a、VEGF-C蛋白表达。结果子宫内膜癌组织中p73a、VEGF-C表达阳性率明显高于正常、增生过长、不典型增生子宫内膜(P<0.01或0.05)。p73a表达与临床分期无关(P>0.05),而VEGF-C表达与临床分期、肌层浸润有关(P<0.01或0.05)。子宫内膜癌组织中p73a与VEGF-C表达呈显著正相关(P<0.05)。结论 p73a、VEGF-C在子宫内膜癌发生、发展中起重要作用,VEGF-C可作为预后判断指标。
Objective To investigate the role of p73a and vascular endothelial growth factor-C (VEGF-C) in the development of endometrial carcinoma. Methods Immunohistochemical S-P method was used to detect the expression of p73a and VEGF-C in normal uterus, proliferative uterus and endometrial carcinoma. Results The positive rates of p73a and VEGF-C in endometrial carcinoma were significantly higher than those in normal, hyperplasia and atypical hyperplasia (P <0.01 or 0.05). The expression of p73a was not related to clinical stage (P> 0.05), but the expression of VEGF-C was correlated with clinical stage and myometrial invasion (P <0.01 or 0.05). There was a significant positive correlation between the expression of p73a and VEGF-C in endometrial carcinoma (P <0.05). Conclusion The expression of p73a and VEGF-C plays an important role in the development of endometrial carcinoma. VEGF-C can be used as a prognostic indicator.