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IL-6不单在免疫系统内而且在造血系统、神经系统、内分泌和代谢系统都表现出多样的生物活性,与多种疾病有关。在体外实验证明,IL-6与IL-3协同使骨髓细胞克隆增加,并促进巨核细胞分化成熟。在体内实验表明,IL-6能增加正常鼠脾脏中CFU-S。促进骨髓移植模型鼠移植后造血系统重建。给予5-FU化疗模型鼠IL-67天后脾脏中造血干细胞/前驱细胞、血小板恢复良好,特异抗体产生增强。在300mg/kg 5-FU(>LD_(50))给药对比试验中,30天生存率对照组为20％,给
IL-6 not only displays diverse biological activities in the immune system but also in the hematopoietic system, nervous system, endocrine and metabolic systems, and is involved in many diseases. In vitro experiments have demonstrated that IL-6 cooperates with IL-3 to increase the clone of bone marrow cells and promote the differentiation and maturation of megakaryocytes. In vivo experiments show that IL-6 can increase CFU-S in the spleen of normal mice. Promote the reconstruction of hematopoietic system after bone marrow transplantation in model mice. After administration of IL-67 for 5 days, the hematopoietic stem cells/precursor cells and platelets in the spleen recovered well and the specific antibody production was enhanced. In the 300 mg/kg 5-FU (>LD_(50)) comparison study, the 30-day survival rate was 20% in the control group.