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在下列病理或生理情况下,应用抗生素或其他抗菌药物时应注意以下几点: 一、肝功能减退时:由于目前常用的肝功能试验不能反映肝脏对抗菌药物的排泄和代谢能力,因此很难根据肝病的严重程度而订出适当的抗菌药物剂量。一般肝功能减退或肝病患者应禁用或慎用经肝内代谢、肝胆系统排泄或对肝脏有损害的抗菌药物,如四坏素类、利福霉素类、大环内酯类抗生素及林可霉素、氯林可霉素、氯霉素、两性霉素B、
In the following pathological or physiological conditions, the application of antibiotics or other antibiotics should pay attention to the following points: First, the time of liver dysfunction: Since the current liver function test does not reflect the liver’s antimicrobial drug excretion and metabolism, it is difficult According to the severity of liver disease and set appropriate doses of antimicrobial agents. General liver dysfunction or liver disease patients should be banned or used with caution by the liver metabolism, liver and gallbladder system excretion of the liver or damaging antibacterial drugs, such as tetracyclines, rifamycins, macrolide antibiotics and Lin Clindamycin, Clindamycin, Chloramphenicol, Amphotericin B,