目的探讨阑尾杯状细胞类癌(GCC)的组织学来源、临床病理特点和生物学行为。方法采用光镜结合免疫组织化学标记对1例阑尾GCC进行研究。结果本例阑尾GCC为男性。镜检肿瘤主要由杯状细胞构成,内含黏液,核位于一侧,无明显异型性,以单个、小巢或腺泡状结构排列,腺泡中央无腔隙,小管状与杯状细胞间及杯状细胞与隐窝上皮问有移行现象,但阑尾腔表面黏膜未见侵犯。免疫组织化学标记CgA,Syn,CEA,CK均阳性。结论阑尾GCC由散在的神经内分泌和黏蛋白分化的多潜能细胞分化而来,是阑尾类癌的一种亚型,诊断主要依靠常规病理、免疫组织化学的综合观察,生物学行为难以预测,可能和肿瘤组成成分及浸润程度有关。 Objective To investigate the histological origin, clinicopathological features and biological behavior of appendicular goblet cell carcinoid (GCC). Methods One case of appendix GCC was studied by light microscopy and immunohistochemistry. Results The appendix GCC was male. Microscopic examination of the tumor consists mainly of goblet cells, containing mucus, the nucleus located on one side, no obvious atypia, arranged in a single, small nest or alveolar structure, with no lacunae in the center of the acinus, between the small tubular and goblet cells. Goblet cells and crypt epithelium asked migration phenomenon, but the surface mucosa of the appendix was not invaded. Immunohistochemical markers were positive for CgA, Syn, CEA and CK. Conclusion The appendix GCC is a subtype of appendix carcinoid, which is derived from the pluripotent cells with scattered neuroendocrine and mucinous differentiation. The diagnosis mainly depends on the comprehensive observation of routine pathology and immunohistochemistry, and the biological behavior is difficult to predict. It is related to the composition of the tumor and the degree of infiltration.