选择生物相容性好 ,可生物降解的壳聚糖蛋白为药物载体 ,并测定了微球粒径 ,药物组分含量及载体自身结构和释药过程等主要物理性能 ,考察了制备工艺中的W/O型分散体系程度、投药量等物理量对形态、粒度、分布和体外降解等的作用。结果表明自制的利福平壳聚糖蛋白微球符合临床使用要求 ,可作为新型缓释药物临床应用 The biocompatible and biodegradable chitosan protein was selected as the drug carrier. The main physical properties of the microspheres such as particle size, drug content, self-structure of the drug carrier and release process were determined. The effects of preparation process W / O-type dispersion system, dosage and other physical quantities on morphology, particle size, distribution and in vitro degradation and so on. The results showed that the homemade rifampin chitosan microspheres in line with clinical requirements, can be used as a new clinical application of sustained release drugs