代谢性碱中毒的特点是血中主要缓冲对——重碳酸盐浓度升高,此与肾脏不能排出过量重碳酸盐有关。近年来的研究提示,慢性代谢性碱中毒与肾小球滤过率(GFR)降低有关。但有人推测,即使 GFR 不下降,肾脏对重碳酸盐的重吸收或许也可能增加,从而使代谢性碱中毒持续存在。心房利钠因子(ANF)能增加单个肾单位和全肾的 GFR,但不改变细胞外 Metabolic alkalosis is characterized by an increase in the concentration of the major buffered para-bicarbonate in the blood, which is associated with the inability of the kidneys to excrete excess bicarbonate. In recent years, research suggests that chronic metabolic alkalosis and glomerular filtration rate (GFR) decreased. However, it was speculated that renal reabsorption of bicarbonate may increase even though GFR does not decrease, leaving metabolic alkalosis persistent. Atrial natriuretic factor (ANF) increases GFR in individual nephrons and whole kidneys but does not alter extracellular