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目的:探讨C反应蛋白(CRP)基因rs2808630多态性与非小细胞肺癌(NSCLC)的相关性。方法:根据连接酶连接反应原理,对上海及江苏泰州地区974例NSCLC患者和1 005例健康人进行CRP基因rs2808630基因分型,分析该位点与NSCLC的相关性。结果:CRP基因rs2808630位点TC较TT患NSCLC风险增加(P=0.034),但校正后不相关。吸烟人群中该位点携带TC基因型者较携带TT基因型者患NSCLC风险增加[比值比(OR)=1.329,95%可信区间(CI)1.017~1.736,P=0.037],携带TC基因型者患鳞癌的风险是携带TT基因型者的1.383倍(95%CI 1.023~1.870,P=0.035);进一步分层分析发现,吸烟人群中携带TC基因型者患NSCLC的风险是携带TT基因型者的1.479倍(95%CI 1.058~2.067,P=0.022)。结论:CRP基因rs2808630T>C可能与吸烟协同导致NSCLC,尤其是鳞癌的发生。
Objective: To investigate the association between rs2808630 polymorphism of C-reactive protein (CRP) gene and non-small cell lung cancer (NSCLC). Methods: According to the principle of ligase ligation, 974 NSCLC patients and 1 005 healthy people in Taizhou, Shanghai and Jiangsu Province were genotyped for rs2808630 CRP gene. The correlation between the locus and NSCLC was analyzed. Results: The TC of CRP rs2808630 was higher than that of TT (P = 0.034), but not after correction. Patients with TC genotype at this locus had a higher risk of NSCLC than those with TT genotype (odds ratio (OR) = 1.329, 95% confidence interval (CI) 1.017-1.736, P = 0.037) The risk of squamous cell carcinoma was 1.383 times (95% CI 1.023-1.870, P = 0.035) in patients with TT genotype. Further stratified analysis found that the risk of NSCLC in TC genotype among smokers was TT 1.479 times (95% CI 1.058 ~ 2.067, P = 0.022) of genotypes. Conclusion: rs2808630T> C of CRP gene may lead to the occurrence of NSCLC especially smoking and squamous cell carcinoma.