Lansoprazole是新一代的质子泵抑制剂。本文旨在早晨服用lansoprazole30mg和60mg两种剂量组与临睡前服用雷尼替了300mg在十二指肠愈合率、症状缓解和安全性方面作一比较。经多中心门诊胃镜室对289例病人采取双育、随机、平行进行为期20个月的研究。病人分为三组，疗程为4周，在 Lansoprazole is a new generation of proton pump inhibitors. This article aims to take lansoprazole 30mg and 60mg morning dose of 300mg and duodenal dose of two doses before going to sleep in duodenal healing rate, symptom relief and safety for a comparison. A multi-center outpatient gastroscopy room was used for 289 patients with double education. Randomized and parallel studies were conducted for 20 months. Patients were divided into three groups, treatment for 4 weeks, at