论文部分内容阅读
PepT2(peptide transporter 2)是一种高亲和力、低容量的转运载体.它在人体中分布广泛,不仅能转运二、三肽,也可以识别和转运许多仿肽类药物,如β-内酰胺抗生素、血管紧张素转换酶抑制剂、贝他定等.研究表明,PepT2的转运机制不同于氨基酸的吸收机制,其底物的仿肽结构特征影响其转运速率.本文综述了PepT2与药物相互作用的研究以及PepT2转运药物底物结构特征的研究进展.
PepT2 (peptide transporter 2) is a high-affinity, low-capacity transporter.It is widely distributed in the body and can not only transport di- and tripeptides, but also recognize and transport many peptides, such asβ-lactam antibiotics , Angiotensin-converting enzyme inhibitors, bentatine, etc. Studies have shown that, PepT2 transport mechanism is different from the amino acid absorption mechanism of its substrate peptide structure characteristics affect its transport rate.This paper reviews the interaction of PepT2 with drugs Research and PepT2 transport drug substrate structural characteristics of research progress.