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为探讨血管内皮生长因子(VEGF)与肺癌血管形成、转移和增殖活性等因素的关系,采用 SP 免疫组织化学方法观察 VEGF 在94例肺癌组织的表达。结果表明,VEGF 在肺癌组织表达的阳性率为70.2%,明显高于癌旁正常组织(P<0.01),VEGF 表达阳性组其微血管计数值和 PCNA标记指数均高于阴性组(P<0.05)。腺癌 VEGF 的表达与转移、分期和分级等因素均无关(P>0.05);在鳞癌有淋巴结转移组 VEGF 的阳性率高于无转移组,Ⅲ～Ⅳ期癌高于Ⅰ～Ⅱ期癌(P<0.05)。上述结果提示,VEGF 表达与肺癌的发生有关,并能促进肺癌组织中的血管形成,使癌细胞的增殖活性升高;VEGF 表达与肺鳞癌淋巴结转移和进展有关,可能是预后不良的标志。
To investigate the relationship between vascular endothelial growth factor (VEGF) and angiogenesis, metastasis and proliferation in lung cancer, SP immunohistochemistry was used to observe the expression of VEGF in 94 lung cancer tissues. The results showed that the positive rate of VEGF expression in lung cancer tissues was 70.2%, which was significantly higher than that in normal tissues (P<0.01). The microvessel counts and PCNA labeling index of VEGF positive group were higher than that of negative tissues (P<0.05). . The expression of VEGF in adenocarcinoma was not related to metastasis, staging and grading (P>0.05). The positive rate of VEGF was higher in squamous cell carcinoma with lymph node metastasis than in non-metastasis, and the carcinoma in III-IV was higher than in stage I-II carcinoma. (P<0.05). The above results suggest that VEGF expression is related to the occurrence of lung cancer, and can promote the formation of blood vessels in lung cancer tissues, and increase the proliferation activity of cancer cells; VEGF expression is related to lymph node metastasis and progression of lung squamous cell carcinoma and may be a sign of poor prognosis.