北京市外来儿童脊髓灰质炎免疫屏障评价

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开展对外来儿童脊髓灰质炎 (脊灰 )抗体水平监测 ,对制定适宜的免疫策略 ,保持无脊灰状态具有重要意义。根据北京市外来人口密集程度和地理分布特点 ,共采集 4个区 1~ 14岁外来儿童血标本 337人测定脊灰抗体水平 ,脊灰Ⅰ、Ⅱ、Ⅲ型中和抗体阳性率分别为 98 5 2 %、99 70 %、95 2 5 % ,几何平均滴度 (GMT)分别为 1∶12 3 0 3、1∶10 9 6 5、1∶5 8 88。 1岁、2~ 4岁儿童各型抗体GMT显著高于 5~ 9岁、10~ 14岁儿童。不同地区间计划免疫管理水平和疫苗接种质量存在差距 ,外来儿童脊灰抗体水平仍低于北京市儿童。 Carrying out the monitoring of polio (polio) antibody levels in children and adolescents is of great importance in formulating appropriate immunization strategies and maintaining polio-free status. According to the density and geographical distribution of migrants in Beijing, a total of 337 blood samples from 4 children aged 1-14 years were collected for the determination of the antibody level of poliovirus. The positive rates of type I, II and III neutralizing antibodies were 98 5 2%, 99 70%, 95 2 5% and geometric mean titers (GMTs) of 1:12 3 0 3, 1 1:10 9 6 5, 1 5 8 88, respectively. 1 year old, 2 to 4 years old children with various types of antibodies GMT was significantly higher than 5 to 9 years old, 10 to 14 years old children. There is a gap between the level of planned immunization management and the quality of vaccination in different regions. The level of poliovirus in foreign children is still lower than that of Beijing children.
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