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目的：1．观察脑出血（CH）、脑梗死（CI）患者降钙素基因相关肽（CGRP）水平改变及其动态变化；2观察CH、CI病情、病灶大小与CGRP水平变化的关系；3．研究CGRP与脑血管病（CVI））伴发疾病的关系；4．探讨CGRP参与各型CVD及其伴发病中的病理生理机制及其临床意义，并探讨其异常分泌的可能机制；5探讨CVD防治的新途径。方法：选择CVD1I8例，其中CH组46例．CI组62例。用放免法检测血浆CGRP浓度。结果：1．CI组CGRP的变化：显著低于对照组，发病24h内即显著降低，2～3d与4～7d则进一步降低，8～15d开始升高，15d后逐渐升至正常水平。伴发病积分＞6分组显著低于＜6分组，高血糖组显著低于正常血糖组。2．CH组CGRP的变化：显著低于对照组．发病24h内即显著降低，2～3d与4～7d进一步降低，8～15d有所升高，15d后进一步升高，仍低于正常水平。随病情加重，脑出血量增加，CGRP水平明显降低。结论：l．CICH患者存在CBRP分泌异常，CGRP参与了CVD的病理生理过程。2．各组CVD、CGRP动态检测可作为病情严重程度、病灶大小及预后的重要指标。3．本研究结果提示，调整CGRP的分泌将有助于改善各组CVD的预后．并为应用CGRP治疗缺血性脑损伤提供了广阔的前景。
Purpose: 1. To observe the changes and dynamic changes of CGRP in patients with cerebral hemorrhage (CH) and cerebral infarction (CI); 2 to observe the relationship between CH, CI’s disease, the size of the lesion and the level of CGRP.3. To study the relationship between CGRP and cerebrovascular disease (CVI) with concomitant diseases; 4. Explore the CGRP involved in various types of CVD and its accompanying pathophysiological mechanisms and their clinical significance, and explore the possible mechanism of abnormal secretion; 5 to explore new ways of prevention and treatment of CVD. Methods: Select CVD1I8 cases, including CH group of 46 cases. CI group of 62 cases. RIA was used to detect plasma CGRP concentration. Results: 1. The change of CGRP in CI group was significantly lower than that in control group, significantly decreased within 24 hours of onset, decreased further from 2 to 3 days and from 4 to 7 days, increased from 8 to 15 days, and gradually rose to normal level from 15 days later. Score> 6 with disease score was significantly lower than <6, high glucose group was significantly lower than normal blood glucose group. 2. CH group CGRP changes: significantly lower than the control group. Within 24 hours after onset, it decreased significantly, decreased further from 2 to 3 days and from 4 to 7 days, increased from 8 to 15 days and further increased 15 days later, still below the normal level. With the aggravation of illness, increased intracerebral hemorrhage, CGRP levels were significantly lower. Conclusion: l. CICH patients have CBRP secretion abnormalities, CGRP involved in the pathophysiology of CVD. 2. Each group of CVD, CGRP dynamic detection can be used as the severity of the disease, the size of the lesion and an important indicator of prognosis. 3. The results suggest that adjusting the secretion of CGRP will help to improve the prognosis of each group of CVD. And for the application of CGRP treatment of ischemic brain injury has provided a broad prospect.