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[目的 ] 探讨遗传因素与环境因素在Ⅱ型糖尿病病因组合中的相互关系 ,比较两者对Ⅱ型糖尿病作用的大小。 [方法 ] 在湖南长沙市 4所医院中 ,按 1∶1配对 (同性别 ,对照与病例年龄相差不超过 5岁 )收集同期诊治的Ⅱ型糖尿病和非Ⅱ型糖尿病 2 0 0对 ,资料采用条件Logistic回归分析。[结果 ] Ⅱ型糖尿病的危险因素有 :糖尿病家族史 (Bi =4 195 ,Bs =2 5 2 3 ,OR =66 3 5 4) ,肥胖 (Bi =2 184,Bs =1 93 2 ,OR =8 882 ) ,肥肉 (Bi =1 2 0 4,Bs =0 814 ,OR =3 3 3 3 ) ,暴饮暴食 (Bi =1 461,Bs =0 75 6,OR =4 3 10 )和甜食 (Bi=0 85 2 ,Bs =0 5 67,OR =2 3 4 4)。 [结论 ] 在Ⅱ型糖尿病的病因组合中 ,遗传因素是最重要的危险因素 ,其次是肥胖、肥肉、暴饮暴食和甜食。但是 ,这些危险因素对导致人群Ⅱ型糖尿病的社会效应以肥胖为最大 ,其次是糖尿病家族史、暴饮暴食、甜食和肥肉。
[Objective] To explore the relationship between genetic factors and environmental factors in the etiology of type Ⅱ diabetes mellitus, and to compare their effects on type Ⅱ diabetes mellitus. [Method] In the 4 hospitals in Changsha, Hunan Province, 2 0 0 pairs of type Ⅱ diabetics and non-type Ⅱ diabetics were collected by 1: 1 pairing (same sex, control and case age difference less than 5 years old) Conditional logistic regression analysis. [Results] The risk factors for type 2 diabetes were family history of diabetes (Bi = 4 195, Bs = 2523, OR = 66344), obesity (Bi = 2 184, Bs = 1 93 2, OR = 8 882), fat (Bi = 1204, Bs = 0 814, OR = 3333), binge eating (Bi = 1 461, Bs = 0 756, OR = 4 3 10) (Bi = 0 85 2, Bs = 0 5 67, OR = 2 3 4 4). [Conclusion] Genetic factors are the most important risk factors in the etiological combination of type Ⅱ diabetes, followed by obesity, fatty meat, binge eating and sweets. However, these risk factors led to the highest prevalence of obesity for the social effects of type II diabetes, followed by family history of diabetes, binge eating, sweets and fat.