目的 :探索围术期使用榄香烯对肺癌手术疗效的影响。方法 :30例中、晚期肺癌患者 ,手术开始静脉滴注榄香烯200mg,术中在肺门、纵隔和受累胸膜周围浸润性注射200mg,术后继续静脉滴注400mg/日达一周。观察术前、出院时患者的WBC计数 ,胸腔引流量 ,术后平均住院天数 ,并发症 ,药物副作用 ,Karnofsky评分。远期随访观察远处转移及胸腔积液形成。29例病情类同 ,单纯手术治疗的患者为对照组。结果 :围术期使用榄香烯不影响伤口愈合 ,术后胸腔引流量减少(P<0 05) ,Karnofsky评分平均提高13 % ,术后WBC计数和术后平均住院天数无差异(P>0 05) ,远期胸腔积液形成减少(P<0 05) ,远处转移率减少14 7 % ,但无差异(P>0 05)。1例患者并发静脉炎 ,2例发热38～38 5℃。结论 :肺癌患者围术期使用榄香烯注射液 ,可改善术后全身情况 ,减少胸腔引流量和远期胸腔积液形成 Objective : To explore the effect of elemene on the curative effect of lung cancer during perioperative period. Methods : 30 patients with advanced and advanced lung cancer were treated by intravenous infusion of elemene 200 mg. Invasive injections of 200 mg were performed in the hilar, mediastinal, and affected pleura during the procedure. Intravenous infusion of 400 mg/day was continued for one week after surgery. The WBC counts, chest drainage, postoperative hospital stay, complications, side effects, and Karnofsky scores were observed before and after discharge. Long-term follow-up observation of distant metastasis and pleural effusion formation. In 29 cases, the patients treated with surgery alone were the control group. Results: Elemene did not affect wound healing during the perioperative period. Postoperative chest drainage decreased (P<0 05), Karnofsky score increased by 13% on average, and there was no difference between postoperative WBC count and postoperative mean length of stay (P>0). 05), the formation of long-term pleural effusion decreased (P <0 05), the distant metastasis rate decreased 147%, but no difference (P> 0 05). One patient had phlebitis and 2 cases had 38 to 38 5°C fever. Conclusion: Elemene injection in patients with lung cancer during perioperative period can improve postoperative general condition, reduce chest drainage and long-term pleural effusion