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目的探讨甲状腺功能亢进性肝功能损害(hyperthyroidism liver injury HLI)的临床特点和影响预后的因素。方法 30例HLI患者临床资料的回顾性总结分析。结果所有患者入院时均存在不明原因肝功能不全,而后明确为HLI。肝功能结果异常主要表现为ALT升高和AST升高为主,其次是GGT、DB、TB、ALP升高以及ALB下降。Logistic回归分析显示入院时TB与HLI患者的预后相关(P<0.05,OR=0.992,95%CI=0.985-0.999)。结论此类患者可同时具备甲亢和肝功不全的临床表现,肝功常表现为淤胆型肝炎。HLI总体预后较好,患者入院时TB升高可能是影响预后的因素。
Objective To investigate the clinical features and prognostic factors of hyperthyroidism liver injury (HLI). Methods The clinical data of 30 patients with HLI were retrospectively analyzed. Results All patients had unexplained liver dysfunction at admission, and then clearly identified as HLI. Abnormal liver function results mainly as ALT elevation and AST elevation, followed by GGT, DB, TB, ALP increased and ALB decreased. Logistic regression analysis showed that TB was associated with the prognosis of patients with HLI on admission (P <0.05, OR = 0.992, 95% CI = 0.985-0.999). Conclusion Such patients may have both clinical manifestations of hyperthyroidism and liver failure, liver manifestations of cholestatic hepatitis. The overall prognosis of HLI is better, and TB elevation may be one of the factors that affect prognosis.