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目的：探讨高原低氧移居者尿液酶Ｎ—乙酰—β—Ｄ—氨基葡萄糖甘酶（ＮＡＧ），γ—谷氨酰转移酶（γ—ＧＴ）、乳酸脱氢酶－Ｌ（ＬＤＨ—Ｌ）、碱性磷酸酶（ＡＬＰ）的排泄变化。方法：对从平原进驻海拨３７００ｍ和５３８０ｍ高原第７天和半年的某部官兵进行尿液检测，且与平原健康青年作对照。结果：高原低氧环境下尿液酶ＮＡＧ、γ—ＧＴ、ＬＤＨ—Ｌ和ＡＬＰ活性均明显高于平原（Ｐ＜０．０５或Ｐ＜０．０１）；初入高原第７天，海拔５３８０ｍ较３７００ｍＮＡＧ和ＡＬＰ活性增高非常显著（Ｐ＜０．０１），γ—ＧＴ和ＬＤＨ—Ｌ活性无显著性差异（Ｐ＞０．０５）；高原居住半年后，ＮＡＧ活性５３８０ｍ较３７００ｍ增高显著（Ｐ＜０．０５），γ—ＧＴ、ＡＬＰ和ＬＤＨ—Ｌ活性变化无显著性差异（Ｐ＞０．０５）。进驻３７００ｍ第７天较半年时ＮＡＧ和γ—ＧＴ显著增高（Ｐ＜０．０５），ＬＤＨ—Ｌ、ＡＬＰ变化无显著性差异（Ｐ＞０．０５）；５３８０ｍ第７天较半年时ＮＡＧ、γ—ＧＴ、ＬＤＨ—Ｌ和ＡＬＰ均显著增高（Ｐ＜０．０５或Ｐ＜０．０１）。结论：高原低氧可导致肾小管上皮细胞通透性增强，重吸收功能降低，肾小球滤过率增加。
Objective: To investigate the relationship between urinary N-acetyl-β-D-glucosaminidase (NAG), γ-glutamyl transferase (γ-GT) and lactate dehydrogenase- ), Excretion of alkaline phosphatase (ALP) changes. Methods: Urine test was conducted on the 7th day and the half year of the 3700m and 5380m altitude plains stationed in the plain and compared with healthy young people in the plain. Results: The activity of NAG, γ-GT, LDH-L and ALP in urine were all significantly higher than those in the plain (P <0.05 or P <0.01) (P <0.01), while there was no significant difference in the activity of γ-GT and LDH-L (P> 0.05). After half a year’s residence in the plateau, the NAG activity 5380m was significantly higher than that of the 3700m (P <0.05). There was no significant difference in the activity of γ-GT, ALP and LDH-L (P> 0.05). There was no significant difference in LDH-L, ALP between NGF and γ-GT at 7th day after entering at 3700m (P <0.05) γ-GT, LDH-L and ALP were significantly increased (P <0.05 or P <0.01). CONCLUSION: Hypoxia on the plateau leads to increased permeability of renal tubular epithelial cells, decreased reabsorption and increased glomerular filtration rate.