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目的:比较地诺前列酮栓(欣普贝生)与缩宫素用于足月妊娠引产的临床效果。方法:研究组140例使用地诺前列酮栓阴道放置促宫颈成熟,诱导产程发动;对照组100例静滴缩宫素引产。两组引产指征无差异,宫颈评分≤6分。观察两组用药后宫颈Bishop评分、分娩情况、母儿结局及副作用。结果:用药后促宫颈成熟有效率研究组为90.2%,而对照组为60.3%,两组比较有统计学意义(P<0.05);从给药到临产时间研究组为15.57±8.51h,对照组为66.71±30.23h,两组比较有统计学意义(P<0.01);阴道分娩率研究组为84.2%,对照组为37%,两组比较有统计学意义(P<0.01);两组中产后出血、胎儿窘迫、新生儿窒息发生率无统计学意义(P>0.05)。结论:欣普贝生用于足月引产安全、有效,尤其适用于宫颈评分≤6分者。
OBJECTIVE: To compare the clinical effects of dinoprostone suppository (Hinbutsbene) and oxytocin for term pregnancy induced labor. Methods: In the study group, 140 cases were treated with droperidol suppository to promote cervix maturation and lead to initiation of labor. In the control group, 100 cases of intravenous oxytocin were induced. Induction of induction of two groups no difference, cervical score ≤ 6 points. The Bishop cervical score, delivery status, maternal and child outcomes and side effects were observed after treatment. Results: The effective rate of cervical ripening was 90.2% in the study group and 60.3% in the control group, with statistical significance (P <0.05). From the time of administration to the time of labor, the study group was 15.57 ± 8.51h, (P <0.01). The rate of vaginal delivery was 84.2% in the study group and 37% in the control group, with significant difference between the two groups (P <0.01). The two groups were statistically significant Postpartum hemorrhage, fetal distress, and neonatal asphyxia had no statistical significance (P> 0.05). Conclusions: Enbubese is safe and effective in term labor induction and is especially suitable for those with cervical score ≤6.