目的探究前列地尔、尿毒清颗粒联合丹参酮注射液对糖尿病肾病患者肾功能、凝血功能和内皮功能的影响及机制。方法将本院收治的90例糖尿病肾病患者随机分为联合组45例(前列地尔、尿毒清颗粒与丹参酮注射液联合治疗)和对照组45例(尿毒清颗粒治疗),检测2组患者治疗前后肾功能、凝血功能和内皮功能指标变化。结果与治疗前比较,治疗后2组患者肾功能指标(Cr、BUN和UAER)、凝血功能指标(TT、PT和FIB)和内皮功能指标(ET-1、v WF和s ICAM-1)显著降低,Ccr、APTT和NO显著升高;联合治疗后患者肾功能指标、凝血功能指标和内皮功能指标显著低于治疗后对照组,Ccr、APTT和NO显著高于治疗后对照组,上述差异均有统计学意义(P<0.05)。结论联合治疗提高了糖尿病肾病患者的血液流通,改善了肾功能,同时调节了血管收缩与舒张。 Objective To investigate the effect and mechanism of alprostin and uremic granules combined with tanshinone injection on renal function, coagulation function and endothelial function in patients with diabetic nephropathy. Methods Ninety patients with diabetic nephropathy admitted to our hospital were randomly divided into 45 combined treatment groups (alprostadil combined with niuduqing granule and tanshinone injection) and 45 control group (treated with nootropic granules), and the patients in two groups were treated Before and after renal function, coagulation and endothelial function index changes. Results Compared with before treatment, the renal function indexes (Cr, BUN and UAER), coagulation function indexes (TT, PT and FIB) and endothelial function indexes (ET-1, v WF and s ICAM-1) Ccr, APTT and NO were significantly increased. After treatment, the indexes of renal function, coagulation function and endothelial function were significantly lower than those of the control group after treatment, and the levels of Ccr, APTT and NO were significantly higher than those of the control group after treatment There was statistical significance (P <0.05). Conclusions Combination therapy increases blood flow in patients with diabetic nephropathy, improves renal function, and regulates vasoconstriction and relaxation.