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目的探讨妊娠中期应用乳杆菌活菌胶囊对早产及先兆早产的预防价值。方法选择石家庄市第四医院2013年门诊产检的妊娠中期的孕妇,筛查出阴道微生态失调1 032例。根据是否接受乳杆菌活菌胶囊治疗分为观察组427例与对照组605例。观察组孕妇睡前温开水冲洗外阴后于阴道后穹窿处放置乳杆菌活菌胶囊1粒,连用10d。10d后行阴道微生态检查,仍异常者再治疗10d。对照组孕妇未进行用药干预治疗。观察并评估观察组孕妇治疗后阴道内乳杆菌阳性率及阴道分泌物清洁度的变化,比较两组孕妇发生早产或先兆早产的情况。结果观察组孕妇治疗后阴道pH(4.04±0.12)较前(4.83±0.09)明显下降(P<0.05);乳杆菌阳性率(81.73%)较前(0.00%)明显上升(P<0.05)。观察组孕妇先兆早产发生率为5.39%,显著低于对照组的8.93%(χ2=4.985,P<0.05);观察组孕妇早产发生率为0.70%,显著低于对照组的2.98%,差异有统计学意义(χ2=5.782,P<0.05)。结论妊娠晚期孕妇阴道微生态失调与先兆早产及早产的发生关系密切,乳杆菌活菌胶囊可恢复正常的阴道微生态环境,降低先兆早产及早产的发生率,对预防先兆早产及早产的风险有一定临床价值。
Objective To investigate the preventive effect of Lactobacillus live in the middle of gestation on premature delivery and threatened premature delivery. Methods Pregnant women of the third trimester of pregnancy in the outpatient clinic of the Fourth Hospital of Shijiazhuang in 2013 were screened, and 1 032 cases of vaginal microecosystem disorders were screened out. According to whether or not to accept Lactobacillus live bacteria capsule treatment group was divided into the observation group of 427 cases and control group of 605 cases. Observation group pregnant women before going to bed warm water to wash the vulva vaginal posterior fornix placed live Lactobacillus 1 capsule, once every 10d. 10d after vaginal microbiological examination, still abnormal and then treated 10d. Pregnant women in the control group were not treated with medication intervention. Observe and evaluate the positive rate of vaginal lactobacilli and vaginal discharge in the observation group after treatment, and compare the incidence of preterm birth or threatened premature labor in the two groups. Results The vaginal pH (4.04 ± 0.12) in the observation group was significantly lower than that before (4.83 ± 0.09) (P <0.05). The positive rate of Lactobacillus (81.73%) in the observation group was significantly higher than that in the former (0.00%) (P <0.05). The incidence of threatened preterm birth in pregnant women in observation group was 5.39%, which was significantly lower than 8.93% in control group (χ2 = 4.985, P <0.05). The incidence of preterm birth in observation group was 0.70%, significantly lower than that in control group (2.98% Statistical significance (χ2 = 5.782, P <0.05). Conclusion Pregnancy women with vaginal microecological disorders in late pregnancy are closely related to the occurrence of threatened premature delivery and premature delivery. Lactobacillus live bacteria capsule can restore normal vaginal microenvironment, reduce the incidence of threatened preterm birth and premature delivery, Certain clinical value.