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近10多年来,移植免疫学的飞速发展及造血干细胞研究的进步,推动了骨髓移植(bone marrow transplantation简称BMT)临床的应用。目前不少学者用BMT治疗再障、急性白血病、急性放射病、恶性淋巴瘤等疾病,并收到了较为满意的效果。但它和其它脏器移植一样,也存在着不少有待解决的问题:如排斥反应、致死性感染、移植物抗宿主病(graft versus host disease简称GVHD)等。尤其GVHD已成为广泛应用BMT的主要障碍。现就与BMT有关的GVHD一些问题加以综述。
In the recent 10 years, the rapid development of transplantation immunology and advances in hematopoietic stem cell research have promoted the clinical application of bone marrow transplantation (BMT). At present, many scholars use BMT treatment of aplastic anemia, acute leukemia, acute radiation sickness, malignant lymphoma and other diseases, and received more satisfactory results. However, like other organ transplantation, there are still many problems to be solved: such as rejection, lethal infection, graft versus host disease (GVHD) and so on. In particular, GVHD has become a major obstacle to the widespread use of BMT. A summary of some of the GVHD issues related to BMT is now available.