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目的:构建兔膝骨关节炎的模型,通过中西医结合的治疗方法研究其对炎症因子的影响。方法:采用关节内注射透明质酸钠配合中药薰洗的治疗方法,检测关节软骨细胞的退变水平。结果:成功建立动物模型,透明质酸钠关节内注射配合千草方薰洗治疗膝关节骨关节炎,能显著延缓关节软骨的破坏。结论:透明质酸钠关节内注射配合千草方薰洗治疗方法能够减轻兔膝骨关节炎的炎症反应。
OBJECTIVE: To establish a model of rabbit knee osteoarthritis and study its effect on inflammatory cytokines through the combination of TCM and Western medicine. Methods: Intra-articular injection of sodium hyaluronate combined with traditional Chinese medicine fumigation treatment, detection of degeneration of articular chondrocytes. Results: Animal models were successfully established. Intra-articular injection of sodium hyaluronate in combination with Qianfang Fang-Xun wash treatment of knee osteoarthritis can significantly delay the destruction of articular cartilage. Conclusion: Intra-articular injection of sodium hyaluronate combined with Qianfang Fang-Xun-washing treatment can reduce the inflammation of rabbit knee osteoarthritis.