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目的:探讨血清胱抑素C(CysC)对于诊断糖尿病肾病(DN)的临床价值。方法:采用免疫比浊法对38例DN患者、32例非糖尿病肾病(NDN)患者和50例正常对照的血清CysC和尿mALB进行测定分析。结果:DN组血清CysC和尿mALB的含量均显著高于NDN组和正常对照组(P<0.01),NDN组和正常对照组间的血清CysC和尿mALB的含量无统计学差异(P>0.05)。三组血清CysC异常检出率分别为:DN组73.7%(28/38),NDN组3.125%(1/32),正常对照组无异常;三组尿mALB异常检出率分别为:DN组52.6%(20/38),NDN组和正常对照组均无异常。结论:血清CysC与尿mALB一样,是诊断糖尿病早期肾损伤的有效指标,具有重要临床价值。
Objective: To investigate the clinical value of serum cystatin C (CysC) in the diagnosis of diabetic nephropathy (DN). Methods: Serum CysC and urine mALB in 38 patients with DN, 32 patients with non-diabetic nephropathy (NDN) and 50 normal controls were measured by immunoturbidimetry. Results: The levels of serum CysC and urinary mALB in DN group were significantly higher than those in NDN group and normal control group (P <0.01). There was no significant difference in serum CysC and urinary mALB between NDN group and normal control group (P> 0.05 ). The detection rates of abnormal CysC in three groups were 73.7% (28/38) in DN group and 3.125% (1/32) in NDN group, respectively. There were no abnormalities in normal control group. The detection rates of abnormal urine mALB in three groups were DN group 52.6% (20/38), no abnormality in NDN group and normal control group. Conclusions: Serum CysC, like urine mALB, is an effective indicator for early diagnosis of diabetic nephropathy. It has important clinical value.