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研究表明,人类恶性肿瘤的发生发展是细胞调控的癌基因、抑癌基因相互作用的结果,多基因变化导致细胞周期紊乱,从而引起细胞失控性生长。因此,近年来对于癌基因和抑癌基因的研究成为讨论肿瘤发生发展的热点。Twist就是近年来倍受关注的癌基因之一,因其参与肿瘤细胞的上皮-间质转变(epithelial-mesenchymal transition,EMT)过程,使肿瘤细胞能通过适应周围基质环境从而获得新的上皮特性,形成转移病灶,且这种转
Studies have shown that the occurrence and development of human malignant tumors are the result of cell-mediated oncogenes and tumor suppressor genes interactions, and multiple gene changes lead to cell cycle disorders, thereby leading to uncontrolled growth of cells. Therefore, in recent years, the study of oncogenes and tumor suppressor genes becomes a hot topic to discuss the development of tumors. Twist is one of the most frequently reported oncogenes in recent years. Because of its involvement in epithelial-mesenchymal transition (EMT) of tumor cells, Twist allows tumor cells to acquire new epithelial properties by adapting to the surrounding matrix environment, The formation of metastatic lesions, and this turn