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目的研究短时间模拟失重对健康人肺功能的影响。方法采用头低位 - 30°模拟短期 ( 4 5min)失重 ,用体描箱对 1 2名健康男性分别于坐位、平卧位、头低位 1 0～ 1 5min ,头低位 45min测量了肺功能的各项指标 ,同时用彩超测量了肺动脉血流和右心功能。并进行了对比分析。结果随着体位由坐位、平卧位到头低位 ,肺通气量 (FVC ,FEV1 ,FEV1 % ,MVV)、肺容量 (VA ,IVC)逐渐减少 ,其中以MVV变化显著 (P <0 .0 0 0 )。而同时随体位变化肺弥散显著增加 ,DLCO(P <0 .0 0 1 ) ,KCO(P <0 .0 0 0 )。结论 -30°、45min头低位时 ,肺通气量、肺容量显著减少。肺弥散量明显增加 ,其中以肺血容量增加 ,肺血流的均匀分布为主要影响因素。
Objective To study the effects of simulated short-term weightlessness on lung function in healthy people. Methods The short-term head-to-toe-30 ° simulated short-term weight loss (45 minutes) was used to measure the changes of lung function in 12 healthy men at sitting position, supine position, head low position 10 ~ 15 min and head low position 45 min Item index, at the same time with color Doppler measured pulmonary artery flow and right heart function. And conducted a comparative analysis. Results The lung capacity (FVC, FEV1, FEV1%, MVV) and the volume of lung (VA, IVC) decreased gradually with the position from the sitting position to the supine position. The changes of MVV were significant (P <0.05) ). At the same time, with the changes of body position, pulmonary diffusion increased significantly, DLCO (P <0.001), KCO (P <0.0000). Conclusions-Lung ventilation and lung volume decreased significantly at -30 ° and 45-min head-low. Diffusion of lung significantly increased, of which pulmonary blood volume increased, the average pulmonary blood flow as the main influencing factors.