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目的改善早产儿的预后，进行早期干预的协作研究。方法将１０３例早产儿随机分为干预组（５２例）和常规育儿组（５１例）。正常对照组（５３例）。干预组从新生儿期开始接受智能早期干预，早产儿两组的围产期情况相似。结果纠正年龄１岁半、２岁时干预组精神发育指数（ＭＤＩ）比常规育儿组平均高１３８和１４６（Ｐ＜０．００１），达正常组水平（Ｐ＞０．０５）。而常规育儿组ＭＤＩ比正常对照组分别低１１５分和８９分（Ｐ＜０．０５）。其中智力低下４例（７．８％）（４／５１），干预组中无一例智力低下。结论早期干预可以促进早产儿智能发育，有利于防治其智力低下。
Objective To improve the prognosis of preterm infants and conduct collaborative research on early intervention. Methods 103 preterm infants were randomly divided into intervention group (52 cases) and conventional child care group (51 cases). Normal control group (53 cases). Intervention group from early neonatal early intelligent intervention, preterm infants in both groups of similar perinatal conditions. Results At the age of 1 year and a half, the mental development index (MDI) of the intervention group was 13.8 and 14.6 (P <0.001) higher than that of the normal group at 2 years of age, reaching the level of the normal group (P> 0.05) . However, MDI in routine parental group was 115 and 89 lower than that in normal control group respectively (P <0.05). Among them, 4 cases had mental retardation (7.8%) (4/51), and none of them in the intervention group had mental retardation. Conclusion Early intervention can promote the intelligent development of premature infants, which is good for prevention and treatment of mental retardation.