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作者等应用体外培养的方法,观察了曼氏血吸虫成虫角皮磷酸水解酶与嘌呤和嘧啶的转运的关系。曼氏血吸虫成虫的多核角皮含有很多腺体、管道和磷酸水解酶有关的结构。作者认为这个角皮结构可能兼有消化和吸收的功能。在体外培养曼氏血吸虫成虫时,一磷酸腺苷(AMP)可以抑制血吸虫摄入介质中的~(14)C-腺嘌呤或~(14)C-腺嘌呤核苷,提示在血吸虫角皮表面存在该核苷酸的水解。AMP水解释放出腺嘌呤核苷,后者使~(14)C-腺嘌呤或~(14)C-腺嘌呤核苷的摄入受到了抑
The authors applied the method of in vitro culture to observe the relationship between Schistosoma mansoni adult keratoderma phosphorylase and purine and pyrimidine transport. The multi-nucleus keratinocytes of the adult Schistosoma mansoni contain many glands, tubes and phosphohydrolase-related structures. The authors believe that this keratin structure may have digestive and absorption functions. In vitro culture of adult Schistosoma mansoni, adenosine monophosphate (AMP) can inhibit the uptake of ~ (14) C-adenine or ~ (14) C-adenosine in the media by Schistosoma japonicum, suggesting that the Schistosoma japonicum surface There is hydrolysis of this nucleotide. AMP hydrolysis releases adenosine, which in turn inactivates ~ (14) C-adenine or ~ (14) C-adenosine