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目的观察门冬胰岛素联合地特胰岛素在妊娠期糖尿病中的治疗效果。方法 80例妊娠期糖尿病患者,随机分为对照组和观察组,每组40例。对照组以门冬胰岛素进行治疗,观察组在其基础上联合地特胰岛素进行治疗,对比两组患者的治疗效果。结果治疗后观察组空腹血糖、餐后2 h血糖及糖化血红蛋白值值分别为(4.82±1.09)、(9.23±2.56)mmol/L、(6.50±1.30)%,对照组分别为(5.59±1.11)、(11.07±3.21)mmol/L、(7.20±1.41)%,组间比较差异具有统计学意义(P<0.05)。观察组低血糖发生率为5%(2/40);对照组为15%(6/40),组间比较差异具有统计学意义(χ~2=8.812,P<0.05)。结论门冬胰岛素联合地特胰岛素在妊娠期糖尿病治疗中效果显著,优于单纯门冬胰岛素治疗,临床上可进行推广应用。
Objective To observe the therapeutic effect of insulin aspart in combination with insulin detemir in gestational diabetes mellitus. Methods 80 cases of gestational diabetes mellitus were randomly divided into control group and observation group, 40 cases in each group. The control group was treated with aspart insulin, and the observation group was treated with insulin dextran on the basis of the comparison. The therapeutic effect was compared between the two groups. Results After fasting, the values of fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin at 2 h were (4.82 ± 1.09), (9.23 ± 2.56) mmol / L and (6.50 ± 1.30)% respectively in the observation group and 5.59 ± 1.11 ), (11.07 ± 3.21) mmol / L and (7.20 ± 1.41)%, respectively. The difference between the two groups was statistically significant (P <0.05). The incidence of hypoglycemia was 5% (2/40) in the observation group and 15% (6/40) in the control group. The difference between the two groups was statistically significant (χ ~ 2 = 8.812, P <0.05). Conclusions Aspart insulin combined with insulin detemir has a significant effect in the treatment of gestational diabetes mellitus, which is superior to simple ascitic insulin therapy and can be applied clinically.