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目的 :探讨HLA B2 7阳性急性前葡萄膜炎的诊断及临床特征。方法 :应用磁珠酶联免疫吸附试验对 74例急性前葡萄膜炎患者和 36例健康对照者血液中HLA B2 7抗原进行测定 ,并对HLA B2 7抗原阳性和阴性急性前葡萄膜炎患者的临床特征进行对比分析。结果 :急性前葡萄膜炎患者 74例中 ,HLA B2 7抗原阳性 35例 ,阳性率为 4 7 30 % ;健康对照者 36例 ,阳性 3例 ,阳性率为 8 33% ;两者有显著性差异 (χ2 =16 2 6 ,P <0 0 1)。HLA B2 7阳性急性前葡萄膜炎的临床特点有起病急、前房内有大量纤维渗出和细胞、角膜后沉着物呈细小、灰白色。一般为单眼发病 ,症状重于常见的特发性前葡萄膜炎 ,复发率较高。常伴有玻璃体混浊、黄斑囊样水肿和全身关节病变。结论 :HLA B2 7抗原与急性前葡萄膜炎明显相关 ,HLA B2 7相关性前葡萄膜炎的临床表现重于HLA B2 7阴性前葡萄膜炎 ,并常伴有全身脊柱关节病变。
Objective: To investigate the diagnosis and clinical features of HLA B2 7 positive acute anterior uveitis. Methods: The HLA B2 7 antigens in 74 patients with acute anterior uveitis and 36 healthy controls were determined by magnetic beads enzyme-linked immunosorbent assay (ELISA), and the HLA-B7 antigens in HLA B2 7 positive and negative patients with acute anterior uveitis Clinical characteristics of comparative analysis. Results: Of 74 patients with acute anterior uveitis, 35 were positive for HLA B2 7 antigen, with a positive rate of 47.30%; 36 healthy controls were positive and 3 were positive, with a positive rate of 8 33% Difference (χ2 = 16 2 6, P <0.01). The clinical features of HLA B2 7 positive acute anterior uveitis are acute onset, a large number of exudative cells in the anterior chamber and cells, corneal posterior deposition was small, gray. Usually monocular disease, symptoms are more common in idiopathic anterior uveitis, a higher recurrence rate. Often accompanied by vitreous opacity, cystoid macular edema and systemic joint disease. CONCLUSION: HLA B2 7 antigen is significantly associated with anterior anterior uveitis. The clinical manifestations of HLA B2 7-associated anterior uveitis are more severe than HLA B2 7-negative anterior uveitis and are often associated with systemic spondyloarthropathy.