卵巢癌是死亡率最高的妇科恶性肿瘤,其发生、发展与多种癌基因有关。端粒酶催化单位(hTERT)是维持端粒酶活性最重要的成分,细胞端粒酶的激活是细胞发生恶变的关键。抗凋亡基因(survivin)是凋亡抑制蛋白家族的成员,能导致细胞凋亡减少,肿瘤形成。目前的研究提示在卵巢癌中两者的表达均增强,且两者可能联合参与卵巢癌的发生、发展,为卵巢癌的诊断及治疗提供依据。 Ovarian cancer is the highest mortality of gynecological malignancies, its occurrence, development and a variety of oncogenes. Telomerase catalytic unit (hTERT) is to maintain the most important component of telomerase activity, cell telomerase activation is the key to cell malignant transformation. The anti-apoptotic gene (survivin) is a member of the apoptosis-inhibitory protein family, leading to reduced apoptosis and tumor formation. The current research suggests that the expression of both in ovarian cancer are enhanced, and both may be involved in the occurrence and development of ovarian cancer, provide the basis for the diagnosis and treatment of ovarian cancer.