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目的:探讨频繁急性加重表型慢性阻塞性肺疾病的临床特征。方法:将2014年1月至2015年10月我科诊治的频繁急性加重表型慢性阻塞性肺疾病及非频繁急性加重表型慢性阻塞性肺疾病稳定期患者随机抽取各50例为观察组和对照组,比较两组白细胞介素-8(IL-8)、降钙素原(PCT)、痰细菌学、慢性阻塞性肺疾病评估测试评分(CAT)、FEV1预计值百分比、FEV1/FVC的差异。结果:观察组IL-8、PCT、痰细菌学阳性率、CAT均明显高于对照组,P均<0.05;而观察组FEV1预计值百分比、FEV1/FVC均明显低于对照组,P均<0.05。结论:频繁急性加重表型慢性阻塞性肺疾病稳定期患者普遍存在细菌定植,细菌定植加剧慢性阻塞性肺疾病稳定期全身炎症反应,并可能是慢性阻塞性肺疾病频繁急性加重的重要因素。
Objective: To investigate the clinical features of frequent acute exacerbations of chronic obstructive pulmonary disease. Methods: From January 2014 to October 2015, 50 patients with severe acute respiratory phenotype chronic obstructive pulmonary disease and non-frequent acute exacerbation of chronic obstructive pulmonary disease who were diagnosed and treated in our department were randomly divided into observation group and control group The levels of IL-8, procalcitonin (PCT), sputum bacteriology, chronic obstructive pulmonary disease assessment test (CAT), percentage of predicted FEV1, FEV1 / FVC difference. Results: The positive rates of IL-8, PCT and sputum in the observation group were significantly higher than those in the control group (P <0.05), while the FEV1 / FVC in the observation group were significantly lower than those in the control group (P < 0.05. Conclusion: Bacterial colonization is common in stable patients with frequent acute exacerbation of chronic obstructive pulmonary disease. Bacterial colonization aggravates the systemic inflammatory response in chronic obstructive pulmonary disease (COPD) and may be an important factor in the frequent acute exacerbation of chronic obstructive pulmonary disease.