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目的：观察急性风湿热(ARF)患儿血清血小板反应蛋白-1(TSP-1)的水平与临床的关系，为疾病的诊断提供一定±据。方法急性风湿热组35例，对照组35例，取血清10μl，应用酶联免疫吸附法(ELISA)检测急性风湿热及对照者血清中TSP-1水平，应用独立资料的t检验分析和Pearson相关性分析对资料进行分析。结果急性风湿热患者血清TS-l的水平明显高于健康对照者[(317.1±103.05)μg/ml VS (206.12±83.65)μg/ml，<0.01]。急性风湿热血清TSP-1与ASO水平呈正相关(r=0.443，<0.05)。结论 TSP-1水平是急性风湿热活动期的血清标记物，对病情诊断具有一定意义。“,”Objective To observe the clinical relationships between Acute rheumatic fever (ARF)and thrombospondin-1 (TSP-1) levels,and provide a basis for the diagnosis of the disease.Methods Compare TSP-1 level in observer group and control group with Enzyme-linked immunosorbent assay (ELISA).Independent t-test analysis and Pearson cor elation analysis wil be analyzed.Results TSP-1 level in observer group is higher than which in control group [(317.1±103.05)μg/ml VS (206.12±83.65)μg/ml,<0.01].Acute rheumatic fever and ASO serum levels of TSP-1 was positively cor elated(=0.443, <0.05). Conclusion TSP-1 levels in acute rheumatic fever is a marker for disease diagnosis and has a certain significance.