All-hydrocarbon stapling strategy has been widely applied for enhancing the proteolytic stability of pep-tides. However, two major technical hurdles to some extent limit the development of stapled peptides for therapeutic usage: rational selection of the
本文介绍了大数据技术以及飞机生产制造方面的相关情况,指出大数据技术在飞机生产制造业供应链质量管控中的应用价值,并从构建平台、做好数据处理工作、完善运行机制、提升监管力度四大方面,具体分析了大数据技术在飞机生产制造业供应链质量管控中应用路径,以期为相关的工作人员提供有价值的参考.
作为一种具有多个优点的焊接方法,激光焊接为目前的研究热点.本文梳理了国内外专利申请整体趋势、国内申请区域布局以及国内外主要申请人类型和申请趋势,对激光焊接进行专利分析.
A visible-light-induced chemoselective reactions of quinoxalin-2(1H)-ones with alkylboronic acids in the presence of air (O2) and N2 atmosphere was developed under transition-metal free conditions, provid-ing 3-alkylquinoxalin-2(1H)-ones and 3,4-dihydroqu
近年来,由于我国社会经济发展速度日益加快,各项事业的生产、发展规模也随之扩大,这直接增加了电力消耗量,使热电厂得到了长足发展.近两年,电力行业随市场经济不断深入,各企业之间竞争也日趋激烈,各热电厂开启寻求稳定效益之路.电力生产离不开汽轮机运行,但不少热电厂在汽轮机运行过程中存在较大的能源浪费情况,除增加电力生产成本外,还限制了电厂的可持续发展.由于我国现阶段正处于节能减排发展的关键时期,所以,热电厂在生产、运行过程中应认识到节能技术的重要性,通过良好应用、优化汽轮机节能技术,有效提升资源利用率.本文通过分
Tumor-associated carbohydrate antigens (TACAs) are attractive targets for vaccine development. In this context, we described a strategy combining artificial TACA and glycoengineering for cancer vaccine devel-opment. A 2,4-ditrophenyl (DNP)-modified GM3 in
As a worldwide public health issue, chronic kidney disease still lacks of effective therapeutic approaches due to the challenges in conventional organ transplantation and dialysis. Renal tissue engineering of-fers an advantageous therapeutic or regenerati
随着科学技术的发展,人民生活水平不断提高,日常生活中涉及的电子设备越来越多,电子设备的电源部分为其工作提供能量.其中,电源的设计尤为重要,电源设计的优越性可以提高设备抗干扰能力和保证电子设备的使用寿命,同时在使用过程中还需注意一些问题.
The replacement of the disulfide bridge of CPI-1, a peptide inhibitor of light chain of Botulinum toxin serotype A, with the thioether-containing and biscarba-containing diaminodiacid bridge leads to a significant decrease in the degradation by trypsin an
Herein, a facile synthesis of valuable pyrido[1,2-a]pyrimidine-4-thiones is reported via novel thiocarbony-lation of C(sp3)-H bonds with carbon disulfide (CS2). This reaction features easy availability of substrates, good functional group tolerance, high