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噻托溴铵和奥洛特罗(olodaterol)复方(Stiolto Respimat)为口腔吸入喷雾剂,用于长期维持治疗慢性阻塞性肺病(COPD)患者,每日1次,使用时间相同,每24 h不可超过2次。噻托溴铵是一种长效毒蕈碱拮抗剂,为抗胆碱能药,具有类似于毒蕈碱亚型受体(M1~M5)的亲和力,通过抑制支气管平滑肌M3受体而发挥药理作用。奥洛特罗是一种长效β2-肾上腺素受体激动剂(long-actingβ2-adrenergic agonist,LABA),吸入后通过结合和激活β2-肾上腺素受体而发挥作用。气道中这些受体被激活后可激活细胞内腺苷酸环化酶,介导c AMP
Tiotropium bromide and olodaterol compound (Stiolto Respimat) are oral inhalation sprays used for long-term maintenance treatment of patients with chronic obstructive pulmonary disease (COPD), once daily, for the same duration of use, not every 24 h More than 2 times. Tiotropium bromide, a long-acting muscarinic antagonist, is an anticholinergic with similar affinities to the muscarinic subtype receptor (M1-M5) and exerts pharmacological effects by inhibiting the bronchial smooth muscle M3 receptor effect. Oloprox is a long-acting beta 2-adrenergic agonist (LABA), which works by binding to and activating the beta 2 -adrenoceptor after inhalation. When activated, these receptors in the airways activate intracellular adenylate cyclase and mediate cAMP