本文系“蒽环类抗生素的化学改造”一组文章中的第二篇。由于4—0—甲基阿克拉霉素A在小鼠身上对血液癌(L1210)表现出理想的活性,所以制备其衍生物来考察结构与抗肿瘤活性之间的关系。文章中共列出六种衍生物,给出它们的化学结构式,并且说明了它们的理化性质。这六种衍生物分别是:4— This article is “anthracycline chemical modification” a group of articles in the second. Since 4-O-methylraclacin A shows an ideal activity on hematological cancer (L1210) in mice, its derivatives were prepared to examine the relationship between structure and anti-tumor activity. The article lists a total of six derivatives, giving their chemical structure, and illustrates their physical and chemical properties. These six derivatives are: 4-