布鲁氏菌病是一种由布鲁氏菌(Brucella)引起的人兽共患病,严重威胁家畜的健康养殖和人类健康。布病的发生和发展受到宿主、病原以及病原在宿主巨噬细胞内定殖等多种因素的影响。布鲁氏菌能在单核细胞尤其是巨噬细胞中生存,并引起机体产生免疫反应,但也是布病难以治愈的原因之一。探究和分析布鲁氏菌引起的免疫应答反应对于布病防控和新型疫苗开发具有重要的意义。现有研究发现,巨噬细胞的主动防御机制、树突状细胞以及由CD4~+和CD8~+亚群介导产生的IFN-γ、IL-12和TNF-α对于抵抗布鲁氏菌的感染十分重要,有关布鲁氏菌特异性免疫应答反应的研究大多集中于小鼠模型。现结合实验室自身研究内容,就国内外布鲁氏菌免疫或感染不同宿主后引起的免疫应答反应进展作一综述。 Brucellosis is a zoonosis caused by Brucella, which seriously threatens the healthy breeding of livestock and human health. The occurrence and development of brucellosis are influenced by many factors such as host, pathogen and pathogen in colonization of host macrophage. Brucella can survive in monocytes, especially macrophages, and cause the body to produce an immune response, but it is also one of the reasons that brucellosis is hard to cure. To explore and analyze the immune response caused by Brucella is of great importance to the prevention and control of brucellosis and the development of new vaccines. Previous studies have found that the active defense mechanism of macrophages, dendritic cells and IFN-γ, IL-12 and TNF-α mediated by CD4 ~ + and CD8 ~ + subsets inhibit Brucella Infection is very important, most of the studies on Brucella-specific immune response focused on the mouse model. Now combined with the laboratory’s own research content, the domestic and foreign brucellosis or immune host infection caused by the immune response to respond to a review.