用离体大鼠胃灌注技术研究不同浓度葡萄糖对胃释放免疫活性胰升血糖素(IRG)及生长抑素(SRIF)分泌的影响。结果提示:(1)葡萄糖可以抑制胃对IRG的释放,浓度越高,释放越少。(2)SRIF在接近生理萄萄糖浓度时释放最多,过高或过低的葡萄糖浓度均抑制SRIF的释放。(3)在低葡萄糖浓度时加入胰岛素使胃释放IRG增加,SRIF则减少。(4)茶硷可以加强精氨酸对离体灌注大鼠胃和胰腺释放IRG及SRIF的刺激作用,提示cAMP系统可能在此两激素分泌过程中起重要作用。 In vitro rat gastric perfusion technique was used to study the effects of different concentrations of glucose on gastric mucosa release of immunostimulatory glucagon (IGF) and somatostatin (SRIF). The results suggest: (1) glucose can inhibit the release of IRG to the stomach, the higher the concentration, the less the release. (2) SRIF released most when approaching physiological glucose concentration, while excessive or low glucose concentration all inhibited the release of SRIF. (3) Insulin was added at low glucose concentrations to increase the release of IRG from the stomach, while SRIF decreased. (4) Theophylline can enhance the stimulating effect of arginine on IRG and SRIF released from gastric perfusion and pancreas in vitro, suggesting that cAMP system may play an important role in the secretion of these two hormones.