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目的:探讨胆胃宁对大鼠乙醇致胃黏膜损伤的修复作用及其机制。方法:32只雄性SD大鼠随机分为正常对照组、模型治疗组、胆胃宁治疗组、奥美拉唑治疗组。正常对照组大鼠采用生理盐水灌胃,其余组以无水乙醇灌胃。2h后分别采用胆胃宁、奥美拉唑灌胃治疗,间隔5h重复上述治疗1次,对比观察各治疗组胃黏膜修复情况。检测治疗前后胃黏膜内丙二醛(MDA)、前列腺素E2(PGE2)及一氧化氮(NO)含量。结果:胆胃宁治疗组大鼠胃PGE2水平,降低胃黏膜MDA及NO含量。结论:胆胃宁能促进急性胃黏膜损伤的修复,其机制可能与降低脂质过氧化,提高抗氧化活力和促进PGE2合成等有关。
Objective: To investigate the reparation of gallstone-induced gastric mucosal damage in rats and its mechanism. METHODS: Thirty-two male Sprague-Dawley rats were randomly divided into normal control group, model treatment group, gallstone treatment group, and omeprazole treatment group. Rats in the normal control group were given intragastric administration of normal saline, and the other groups were intragastrically administered with anhydrous ethanol. Two hours later, giagenin and omeprazole were intragastrically administered. The above treatments were repeated at intervals of 5 hours. The gastric mucosal repair was observed in each treatment group. The contents of malondialdehyde (MDA), prostaglandin E2 (PGE2) and nitric oxide (NO) in the gastric mucosa were measured before and after treatment. Results: The level of gastric PGE2 in the gall bladder-treated group decreased the content of MDA and NO in gastric mucosa. CONCLUSION: Galling can promote the repair of acute gastric mucosal injury. The mechanism may be related to the reduction of lipid peroxidation, increase of antioxidant activity and promotion of PGE2 synthesis.