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生长抑素及其类似物对正常细胞和肿瘤的生长增殖具有抑制作用。生长抑素的作用是通过与其受体结合而发挥的,其受体有5个亚型,其中2型受体与抑制细胞增殖的关系较为密切,由于生长抑素作用的大小往往取决于组织所表达的受体数目,因此测定胃组织中生长抑素2型受体(SSR2)的表达可以反映出生长抑素的作用情况。我们的目的是建立测定胃粘膜组织SSR2的方法,由于内镜活检组织较小,测定受体蛋白比较困难,所以,我们采用测定SSR2mRNA的方法,间接反映SSR2的水平。
Somatostatin and its analogues have inhibitory effects on the growth and proliferation of normal cells and tumors. The role of somatostatin is through its receptor binding and its receptor has five subtypes, of which type 2 receptor and inhibition of cell proliferation is more closely related to the size of the role of somatostatin often depends on the organization Therefore, the determination of somatostatin type 2 receptor (SSR2) expression in gastric tissue may reflect the effect of somatostatin. Our aim is to establish a method for the determination of SSR2 in gastric mucosa. Because of the small tissue size of the endoscopic biopsy and the determination of the receptor protein, it is difficult to determine the SSR2 mRNA level. Therefore, SSR2 mRNA level indirectly reflects the SSR2 level.