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目的:研究缬草素的抗焦虑作用。方法:雄性SD大鼠60只,随机分为5组:缬草素高、中、低剂量组(剂量分别为20,10,5 mg·kg-1)、阳性药地西泮(diazepam,DZP)组和空白组,ig 10 d后采用国际通用的高架十字迷宫(elevated plusmaze,EPM)焦虑动物模型,从行为学角度观察了缬草素的抗焦虑作用。结果:EPM行为学观察表明:与空白组相比,DZP和缬草素中剂量组可明显提高大鼠在开臂时间百分率(14.07%,38.09%,37.42%,P<0.01)和次数百分率(16.98%,30.10%,37.19%,P<0.05或P<0.01)。结论:缬草素有明显的抗焦虑作用。
Objective: To study the anti-anxiety effect of Valerian. Methods: Sixty male Sprague-Dawley rats were randomly divided into five groups: high, middle and low doses of valulein (doses of 20, 10 and 5 mg · kg-1, respectively), diazepam ) Group and the blank group. The anxiolytic animal model of elevated plusmaze (EPM) was adopted after 10 days. The anti-anxiety effect of Valerian was observed from the behavioral point of view. Results: EPM behavioral observation showed that compared with the blank group, DZP and Valerian mid-dose groups could significantly increase the percentage of open arm time (14.07%, 38.09%, 37.42%, P <0.01) 16.98%, 30.10%, 37.19%, P <0.05 or P <0.01). Conclusion: Valerian has obvious anti-anxiety effect.