论文部分内容阅读
目的 :探讨丙氟沙星对奥曲肽治疗食管静脉曲张出血 (EVB)的影响及其机理 :方法 :6 0例EVB患者 ,随机分 2组 ,分别给予奥曲肽、奥曲肽联合丙氟沙星治疗。结果 :EVB患者 6、12、2 4h止血率、治疗前后血清一氧化氮 (NO)含量 ,奥曲肽组分别为 2 7%、40 %、6 3%、(6 9± 0 8)umol L、(5 6± 0 9)umol L(P <0 .0 5 ) ;奥曲肽联合丙氟沙星组分别为 5 0 %、70 % (P <0 .0 5 )、93% (P <0 .0 5 )、(7.3± 0 .6 )umol L、(4.3± 0 .7)umol L(P<0 .0 5 )。结论 :丙氟沙星明显提高奥曲肽治疗EVB的疗效 ,其机理可能与降低血清NO含量有关。
Objective: To investigate the effect and mechanism of ciprofloxacin on octreotide in patients with esophageal variceal hemorrhage (EVB): Methods: Sixty EVB patients were randomly divided into two groups and were treated with octreotide and octreotide combined with ciprofloxacin respectively. Results: The hemostatic rates at 6, 12, and 24 hours were significantly higher in patients with EVB than those in patients with octreotide (27%, 40%, 63%, (69 ± 0 8) umol L, 5 6 ± 0 9) umol L (P <0 05). The octreotide and cofloxacin groups were 50%, 70% (P <0.05), 93% (P <0.05) ), (7.3 ± 0.6) umol L, (4.3 ± 0.7) umol L (P <0.05). Conclusion: Cloveloxacin significantly improves the efficacy of octreotide in the treatment of EVB. The mechanism may be related to the decrease of serum NO level.