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自1909年发现脊髓灰质炎(简称脊灰炎)病毒后不久,即开始致力于疫苗的研究。1954年 Salk 氏试制成功了脊灰炎灭活疫苗,此后 Sabin 氏等于1959年开始应用脊髓灰质炎减毒活疫苗(简称脊灰活疫苗)。每一种活疫苗开始使用,都会引起人们首先对其安全性的关注,也就是接种这种活疫苗会不会发生相应的疾病的问题。对于脊灰活疫苗也不例外。1961年以前,就有人报
Shortly after the discovery of the poliovirus (polio) virus in 1909, it began to work on the vaccine. 1954 Salk’s trial of polio inactivated vaccine was successful, then Sabin equivalent to the beginning of 1959 live attenuated polio vaccine (referred to as polio live vaccine). Each kind of live vaccine starts to use, will cause people to pay attention to its security first, that is to vaccinate this live vaccine to be able to have the corresponding disease the question. Live polio vaccine is no exception. Before 1961, someone reported