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目的:通过比较自然受孕和辅助生殖技术(ART)受孕先兆流产患者的妊娠结局,探讨影响ART妊娠成功率的相关因素。方法:选取2006年1月～2009年12月因早孕先兆流产住院的患者,根据不同受孕方式分为自然受孕组和ART受孕组两组,对其临床资料进行回顾性分析。结果:ART受孕组的年龄较自然受孕组大,差异有统计学意义(P<0.05);ART受孕组宫腔操作次数较自然受孕组多(P<0.05);ART受孕组的双胎妊娠率较自然受孕组高(P<0.05);ART受孕组妊娠成功率较自然受孕组低(P<0.05);ART受孕组妊娠晚期并发症、剖宫产率较自然受孕组高(P<0.05)。结论:年龄、多胎妊娠、多次宫腔操作是影响ART妊娠成功率及妊娠晚期并发症的主要因素。在辅助生殖技术中要减少多胎妊娠的发生,规范临产操作技术,注意宫颈机能的保护。有多次宫颈操作史者,妊娠期应严密监测宫颈情况,必要时行宫颈环扎术。
Objective: To compare the pregnancy outcomes of patients with threatened abortion under natural conception and assisted reproductive technology (ART), and to explore the factors influencing the success rate of ART pregnancy. Methods: The patients hospitalized for threatened abortion in early pregnancy from January 2006 to December 2009 were divided into two groups according to different methods of conception: spontaneous conception group and ART conception group. The clinical data of the patients were retrospectively analyzed. Results: The age of ART conception group was larger than that of spontaneous conception group (P <0.05). The number of uterine cavity operation in ART conception group was more than that of spontaneous conception group (P <0.05) (P <0.05). The pregnancy success rate in ART conception group was lower than that in spontaneous conception group (P <0.05). The incidence of complications and cesarean section rate in ART conception group was higher than that in spontaneous conception group (P <0.05) . Conclusion: Age, multiple pregnancy and multiple uterine operations are the main factors affecting the success rate of ART pregnancy and the complications of late pregnancy. In assisted reproductive technology to reduce the incidence of multiple pregnancies, standardized abortion operation techniques, pay attention to the protection of cervical function. There are many times the history of cervical operation, pregnancy should be closely monitored cervical conditions, if necessary, cervical cerclage.