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目的检测血清IL-18和脂联素在早产妊娠妇女血清中的含量,以探讨上述指标与对宫内感染预测的关系。方法选取宫内感染妊娠妇女43例作为宫内感染组,同时选取同期进行产前检查的妊娠妇女40例为对照组。分别抽取空腹静脉血进行IL-18和脂联素含量的检测。结果宫内感染组IL-18含量均高于对照组的含量,差异具有显著性(P<0.01);宫内感染组中脂联素含量均低于对照组含量,差异具有显著性(P<0.01);IL-18和脂联素的含量呈负相关(r=-0.65,P<0.01)。结论IL-18和脂联素的含量在宫内感染中存在显著性变化,可作为预测宫内感染的辅助诊断指标。
Objective To determine the serum levels of IL-18 and adiponectin in pregnant women with preterm labor to explore the relationship between these indices and the prediction of intrauterine infection. Methods Forty-three pregnant women with intrauterine infection were selected as intrauterine infection group. Forty pregnant women with prenatal examination during the same period were selected as the control group. Fasting venous blood samples were taken for determination of IL-18 and adiponectin. Results The content of IL-18 in intrauterine infection group was higher than that in control group (P <0.01). The content of adiponectin in intrauterine infection group was lower than that in control group (P < 0.01). The content of IL-18 and adiponectin were negatively correlated (r = -0.65, P <0.01). Conclusion The contents of IL-18 and adiponectin in patients with intrauterine infection have significant changes, which can be used as an auxiliary diagnostic index to predict intrauterine infection.