染色体21-三体综合征病人易于感染,一旦感染其病死率较正常人群高。许多实验研究证实本病的细胞、体液免疫力以及吞噬功能不正常。文献报告该病的血清锌水平降低。已知锌参与细胞的多种生物活性,在肠病性肢端皮炎和营养不良病例中,锌缺乏与免疫异常有关。本文给12例8～22岁(男7例,女5 Chromosome 21 - trisomy syndrome patients susceptible to infection, once infected with higher mortality than the normal population. Many experimental studies have confirmed that the disease cells, humoral immunity and phagocytosis is not normal. The literature reports a decrease in serum zinc levels. Zinc is known to be involved in a wide range of cellular bioactivities and is associated with an abnormal immune response in enteric acral dermatitis and malnutrition cases. This article gives 12 cases of 8 to 22 years old (7 males and 5 females