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目的探讨枯草杆菌二联活菌肠溶胶囊联合美沙拉嗪肠溶片治疗溃疡性结肠炎的临床疗效。方法选取贺州市人民医院2014年5月—2016年5月收治的溃疡性结肠炎患者86例,随机分为对照组和治疗组,各43例。对照组予以美沙拉嗪肠溶片治疗,治疗组在对照组基础上加用枯草杆菌二联活菌肠溶胶囊治疗,两组患者均计划治疗1个月。比较两组患者临床疗效、症状消失时间和药物治疗时间、实验室指标〔白介素8(IL-8)、肿瘤坏死因子α(TNF-α)、超氧化物歧化酶(SOD)、丙二醛(MDA)〕及不良反应发生情况。结果治疗组临床疗效优于对照组,症状消失时间、药物治疗时间短于对照组(P<0.05)。治疗前两组患者IL-8、TNF-α、SOD、MDA水平比较,差异无统计学意义(P>0.05);治疗后治疗组患者IL-8、TNF-α、MDA水平低于对照组,SOD水平高于对照组(P<0.05)。治疗组患者药物不良反应发生率低于对照组(P<0.05)。结论枯草杆菌二联活菌肠溶胶囊联合美沙拉嗪肠溶片治疗溃疡性结肠炎的临床疗效确切,可有效改善患者肠道功能,且不良反应少。
Objective To investigate the clinical efficacy of Bacillus subtilis bivalent enteric-coated enteric-coated capsules combined with mesalazine enteric-coated tablets in the treatment of ulcerative colitis. Methods Totally 86 patients with ulcerative colitis admitted to Hezhou People’s Hospital from May 2014 to May 2016 were randomly divided into control group and treatment group, with 43 cases in each group. The control group was treated with mesalazine enteric-coated tablets. The treatment group was treated with B. subtilis enteric-coated enteric-coated capsules on the basis of the control group. Both groups were planned to be treated for 1 month. The clinical efficacy, symptom disappearance time and drug treatment time were compared between the two groups. The laboratory parameters (IL-8, TNF-α, SOD, MDA MDA)] and adverse reactions occurred. Results The clinical curative effect of the treatment group was better than that of the control group. The symptom disappear time and drug treatment time were shorter than the control group (P <0.05). The levels of IL-8, TNF-α, MDA and MDA in the two groups before treatment were not significantly different (P> 0.05). The levels of IL-8, TNF-α and MDA in the treatment group were lower than those in the control group SOD level was higher than the control group (P <0.05). The incidence of adverse drug reactions in the treatment group was lower than that in the control group (P <0.05). Conclusion Bacillus subtilis bivalent enteric-coated enteric-coated capsules combined with mesalazine enteric-coated tablets for the treatment of ulcerative colitis have definite curative effect, which can effectively improve the intestinal function of patients with less adverse reactions.