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目的：研究血糖波动对2型糖尿病患者脂肪酸结合蛋白的影响。方法2型糖尿病患者40例，健康者20例，测定空腹血糖、餐后2小时血糖、糖化血红蛋白、体重指数、血压，总胆固醇、甘油三酯、脂肪细胞型脂肪酸结合蛋白，按血糖波动将2型糖尿病患者分为A组（差值＜6mmol/L），B组（差值≧6mmol/L），比较各组脂肪细胞型脂肪酸结合蛋白水平。结果血糖波动越大，脂肪细胞型脂肪酸结合蛋白浓度越高结论2型糖尿病患者血糖波动与脂肪细胞型脂肪酸结合蛋白浓度相关，可作为评估2型糖尿病危险因素指标之一。“,”Objective To study the relationship between blood glucose fluctuations and adipocyte fatty acid binding protein in patients with type 2 diabetes. Methods 40 patients with type 2 diabetes and 20 healthy people, examine the fasting plasma glucose(FPG), 2-hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbAlc),body mass index(BMI), blood pressure(BP), cholesterol(TC),triglyceride (TG), Adipocyte fatty acid binding protein(A-FABP).According to the blood glucose fluctuations ,we divided 40 patients with type 2 diabetes into 2 groups:A group(difference<6mmol/L),B group(difference≧6mmol/L), and the A-FABP levels were compared between them. Results The larger the blood glucose fluctuations,the higher adipocyte fatty acid binding protein concentration. Conclusion The blood glucose fluctuations of the patient with type 2 diabetes is closely related with adipocyte fatty acid binding protein concentration,and may serve as a useful marker for the type 2 diabetes.