eFlow成像评价重组蛋白疫苗联合低剂量吉西他滨抗小鼠肿瘤血管生成

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目的探讨彩色多普勒成像技术(CDFI)与高频超声结合eFlow成像技术在评价鸡FGFR1重组蛋白联合低剂量吉西他滨抗小鼠肿瘤血管生成疗效中的价值。方法 40只小鼠皮下接种2×106个肿瘤细胞(Meth A模型),7 d后随机分成以下4组(10只/组):cFR蛋白疫苗联合低剂量吉西他滨治疗组(C+G组)、cFR蛋白疫苗单独治疗组(cFR组)、低剂量吉西他滨单独治疗组(G组)、生理盐水非治疗对照组(NS组)。于分组后第4周使用CDFI及高频超声eFlow显像显示小鼠肿瘤内微血管的走行和分布,并计算瘤
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