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对９例新生儿先天性巨结肠（ＨＤ）肠炎和１６例新生儿坏死性小肠结肠炎（ＮＥＣ）的病理分析，发现ＮＥＣ累及的范围较ＨＤ肠炎广泛，ＮＥＣ肠段的出血、炎症也较ＨＤ肠炎严重。结合２１例动物实验的结果，初步探讨了ＨＤ肠炎和ＮＥＣ发病机理。远端梗阻，近端扩张，肠内压力升高，局部血供减少，滞留粪便中的细菌繁殖、侵入肠壁是ＨＤ肠炎的主要原因；而新生儿有窒息、休克缺氧时，小肠、结肠的血液供应减少，加上免疫变态反应的参与，肠道粘膜缺乏ＩｇＡ的保护，肠道致病菌的过度繁殖、侵入肠壁是ＮＥＣ的发病原因。
Nine cases of neonatal Hirschsprung’s disease (enterocolitis) and 16 cases of neonatal necrotizing enterocolitis (NEC) pathological analysis found that the scope of NEC involvement than the wide range of HD enteritis, NEC intestinal bleeding, inflammation than HD Enteritis serious. Combined with the results of 21 animal experiments, preliminary study of the pathogenesis of HD enteritis and NEC. Distal obstruction, proximal dilatation, increased intestinal pressure, local blood supply, retention of bacteria in feces, enter the intestinal wall is the main cause of HD enteritis; neonatal asphyxia, shock, hypoxia, small intestine, colon Reduced blood supply, coupled with immune allergic involvement, the lack of protection of intestinal mucosa of IgA, intestinal overgrowth of pathogens, invasion of the intestinal wall is the cause of NEC.